Researchers identify key brain proteins responsible for epilepsy development.  The new research “could potentially change textbooks” on epilepsy and call for new treatments, according to the investigators.

An estimation by the World Health Organization (WHO) notes that 50 million people in the world have epilepsy. It is one of the most common neurological conditions in the world. There are 3.4 million people — or 1.2 percent of the population – who are suffering from this condition in America. Epilepsy is a disorder in which rain activity becomes abnormal, causing disruption in the normal neurological function.

Nerve cells send electrical signals to each other on which healthy-functioning brain relies. So, understanding the interaction between nerve cells could help treat epilepsy more efficiently.

Led by Rochelle Hines, a researcher at the University of Nevada, Las Vegas, and the researchers conducted a new study to discover the dynamic of the electrical signaling of neurons. They conducted the researchers on mice

After the trial, the researchers found type-A GABA (GABAA) receptors the main players in the dynamic between excitatory cells and inhibitory neurons.

“That’s the piece that could potentially change textbooks: Previously, we had questions about how these pieces fit together and thought that maybe a group of three or more proteins interacted,” Rochelle Hines explains.

“But our team’s research strongly suggests that there’s a very specific interaction between two of them, and this has implications for how neuroscientists might be able to regulate this area,” Rochelle Hines added.



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