Aging together with obesity affects brain, boosting Alzheimer’s risk, a new study found. The effects of natural aging processes, obesity, and a poor diet, all jointly prime the brain that causes the risk of Alzheimer’s.

Alzheimer’s disease is a progressive mental deterioration that destroys memory and other important mental functions.  The development of this condition can occur due to some risk factors including aging and metabolic conditions such as obesity and diabetes. Many of the biological causes of the arrival and development of this condition are unknown.

A study conducted by Rebecca MacPherson, Bradley Baranowski, and Kirsten Bott from Brock University in Ontario, Canada that wanted to discover some more mechanics behind the development of this type of dementia.

The researchers experimented on aging mice to find out how a high-fat, high-sugar (HFS) diet that caused obesity can also prime the brain for neurodegeneration.

The research which says aging together with obesity affects brain, causing the Alzheimer’s Risk was published in a paper now published in the journal Physiological Reports.

The group of mice was given food rich in fat and sugar content. After 13 weeks, they analyzed signs of inflammation and looked at cellular stress levels in two brain areas associated with memory and cognitive behavior: the hippocampus and the prefrontal cortex.

As a result, mice on an obesity-inducing diet were found with high levels of brain inflammation and cellular stress.

“These results add to our basic understanding of the pathways involved in the early progression of Alzheimer’s pathogenesis and demonstrate the negative effects of an HFS diet on both the prefrontal cortex and hippocampal regions,” researchers notes.



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